NEK7 promotes gastric cancer progression as a cell proliferation regulator

Abstract Background Gastric cancer is one of the most common malignant tumors digestive system. However, its targeted therapy develops at a slow pace. Thus, exploring mechanisms behavior gastric cells crucial to exploit treatment. Mammalian never-in-mitosis A (NIMA)-related kinases (NEKs) are considered play significant role in cell proliferation. no study has reported on NIMA family proteins cancer. Methods Bioinformatics analysis was employed clarify expression patterns NEK1–NEK11 and their effects prognosis. The NEK7 immune infiltration related pathways were also analyzed. At level, 5-ethynyl-2-deoxyuridine, cycle, Cell Counting Kit-8 assays utilized effect mouse subcutaneous model revealed regulating proliferation vivo. Results that upregulated poor T-stage, which closely associated with Further showed correlated multiple as well cancer-related pathways. experiments indicated promoting proliferation, while absence could lead inhibition G1/S arrest. Conclusion exerts regulatory tumor infiltration.